Mesothelioma Asbestos – Research and Lawsuit Information

Date Added: February 10, 2010 12:11:42 PM

Author: Monty Wrobleski

According to a 2005 Rand Institute Study, over 730,000 people in the United States filed claims for asbestos induced injuries through 2002. Asbestos is a class of minerals that is used in construction materials and products. Its widespread use was attributed to its fire resistance and strengthening properties. Asbestos Litigation relies on several different legal theories including strict liability, negligence, and failure to warn.

Asbestos Litigation can be very difficult for a number of reasons. First, it can be difficult to collect evidence and determine where the exposure took place. It is also difficult tracking down witnesses because the exposure happened so long ago. Another problem is that the victims of asbestos exposure are extremely ill.

One important study that investigated mesothelioma is called, “Mesotheliomata in Rats after Inoculation with Asbestos and Other Materials” by J. C. Wagner, G. Berry, and V. Timbrell - Br J Cancer. 1973 August; 28(2): 173–185.

Here is an excerpt:

“Four experiments in which SPF Wistar rats were inoculated intrapleurally with asbestos or other materials are described. Mesotheliomata were observed in a considerable proportion of animals with all the samples of asbestos used and with a sample of brucite. A few were produced with synthetic aluminium silicate fibres and single ones with barium sulphate, glass powder and aluminium oxide. The risk of developing a mesothelioma at a given time after injection was approximately proportional to the dose. Of the UICC standard reference samples, crocidolite was the most carcinogenic and removal of the oils by benzene extraction did not alter the carcinogenicity of these samples. Chemical properties also seem unlikely to be the main factor producing mesotheliomata but the results support the hypothesis that the finer fibres are the more carcinogenic, and this is additional to the known aerodynamic advantage which the finer fibres have in penetrating to the periphery of the lung.”

Another important study is called, “Chrysotile asbestos inhalation in rats: deposition pattern and reaction of alveolar epithelium and pulmonary macrophages” by
Brody AR, Hill LH, Adkins B Jr, O'Connor RW. Am Rev Respir Dis. 1981 Jun;123(6):670-9. Here is an excerpt:

“The initial deposition and subsequent translocation of chrysotile asbestos were studied in the lungs of rats exposed for 1 h in inhalation chambers. Using scanning and transmission electron microscopy of tissue fixed by vascular perfusion, we determined that the majority of fibers that pass through the conducting airways deposits at the bifurcations of alveolar ducts. The farther an alveolar duct bifurcation was from its terminal bronchiole, the less asbestos were observed. The amount of asbestos present on the alveolar duct surfaces was significantly decreased 5 h after cessation of the 1-h exposure. Some fibers were taken up by Type I epithelial cells during the first hour of dusting, and this process continued through the 8-day period in which the animals were studied. As early as 24 h after exposure, there was an accumulation of macrophages at the sites of initial asbestos deposition. This may be a significant cellular response in the early pathogenesis of asbestosis.”

Continued research and dedication is needed if we are ever to find a cure to these horrible diseases.

Monty Wrobleski is the author of this article on Asbestos Attorney. Find more information about Asbestos Lawyer here.

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